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Results for "

Pyruvate dehydrogenase complex (PDC)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PDHK (1)
By Research Areas:	Cancer (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

PDHK1-IN-1	PDHK	Cancer
PDHK1-IN-1 (compound 17) is a selective inhibitor of PDHK1 (IC₅₀=1.5 μM) with anticancer activity. PDHK1 negatively regulates the pyruvate dehydrogenase complex (PDC), limiting the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Overexpression of PDHK1 can shift the metabolism towards an increased glycolysis dependence (Warburg effect). PDHK1-IN-1 can inhibit the phosphorylation of the PDC E1α Ser232 recognition site of PDHK1 and the phosphorylation of Ser293 .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71676

	PDCE2 Protein, Mouse (HEK293, His) 2 Publications Verification Dlat; Dihydrolipoyllysine-residue acetyltransferase component of Pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2	Mouse	HEK293
	PDCE2 Protein, a vital element in the pyruvate dehydrogenase complex, is integral to cellular metabolism. It catalyzes the conversion of pyruvate to acetyl-CoA and CO2, connecting glycolysis to the tricarboxylic acid (TCA) cycle. PDCE2's catalytic function is essential for efficient pyruvate utilization, ensuring the flow of carbon compounds through key metabolic pathways crucial for energy production and cellular homeostasis. PDCE2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PDCE2 protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P75286

	DLAT Protein, Human (sf9, His) Pyruvate dehydrogenase complex component E2; PBC; PDC-E2; DLAT; DLTA	Human	Sf9 insect cells
	DLAT protein is an important component of the pyruvate dehydrogenase complex, which mainly promotes the conversion of pyruvate into acetyl-CoA and CO2. This enzymatic step establishes a critical link between glycolysis and the tricarboxylic acid (TCA) cycle. DLAT Protein, Human (sf9, His) is the recombinant human-derived DLAT protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Host:	Mouse (2)
Reactivity:	Human (1) Mouse (1) human (1)
Application:	IHC-P (1) ICC/IF (2) IF-Tissue (1) IP (2) WB (2) ELISA (1)
Isotype:	IgG1 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (2)

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HY-P85556

	Pyruvate Dehydrogenase E2 Antibody (YA5248) 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; anti DLAT; Dihydrolipoamide acetyltransferase component of Pyruvate dehydrogenase complex; Dihydrolipoamide; Dihydrolipoamide S Acetyltransferase; Dihydrolipoamide S-acetyltransferase; E2 component of Pyruvate dehydrogenase complex; Dihydrolipoamide S-Acetyltransferase; Dihydrolipoyllysine-residue acetyltransferase component of Pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of Pyruvate dehydrogenase complex mitochondrial; DLAT; DLAT; DLTA; E2; E2 component of Pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; M2 Antigen complex 70kD Subunit; mitochondrial; ODP2_HUMAN; PBC; PDC E2; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2; Pyruvate dehydrogenase complex E2 subunit; S acetyltransferase component of Pyruvate dehydrogenase complex.	WB, ICC/IF, IP	Human, Mouse
	Pyruvate Dehydrogenase E2 Antibody (YA5248) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E2.

HY-P89693

	E3BP Antibody (YA9037) DLTA, DLAT, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, Dihydrolipoamide acetyltransferase component of Pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, Pyruvate dehydrogenase complex component E2, PBC, PDC-E2, PDCE2	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	E3BP Antibody (YA9037) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to E3BP.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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